Cost-effectiveness of Haemophilus influenzae type b vaccine in low- and middle-income countries: Regional analysis and assessment of major determinants
نویسندگان
چکیده
Objectives To estimate the cost-effectiveness of Hib vaccine in low-and middle-income countries and identify the model parameters which are most important for the result. A static decision tree model was developed to predict incremental costs and health impacts. Estimates were generated for four country groups: Countries eligible for funding by the GAVI Alliance in Africa and Asia, lower middle-income countries and upper middle-income countries. Parameter values, including disease incidence, case fatality rates and treatment costs, were based on international country estimates and the scientific literature. Results From the societal perspective, it is estimated that the probability of Hib vaccine being cost saving is 53% and 34% in GAVI eligible African and Asian countries, respectively. In middle-income countries, costs per discounted DALY averted are between US$ 37 and US$ 733. Variation in vaccine prices and risks of meningitis sequelae and mortality explain most of the difference in results. For all country groups disease incidence parameters cause the largest part of the uncertainty in the result. Conclusion Hib vaccine is cost saving or highly cost-effective in low-and middle-income settings. This conclusion is especially influenced by the recent decline in Hib vaccine prices and new data revealing the high costs of lost productivity associated with meningitis sequelae.
منابع مشابه
Haemophilus influenzae type b vaccine in low- and middle-income countries: Impact, costs and incremental cost-utility
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